Number of the records: 1  

Caspase-7 in molar tooth development

  1. 1.
    SYSNO ASEP0386731
    Document TypeJ - Journal Article
    R&D Document TypeJournal Article
    Subsidiary JČlánek ve WOS
    TitleCaspase-7 in molar tooth development
    Author(s) Matalová, Eva (UZFG-Y) ORCID
    Vanden Berghe, T. (BE)
    Švandová, Eva (UZFG-Y) RID, ORCID
    Vandenabeele, P. (BE)
    Healy, C. (GB)
    Sharpe, P. T. (GB)
    Tucker, A. S. (GB)
    Source TitleArchives of Oral Biology. - : Elsevier - ISSN 0003-9969
    Roč. 57, č. 11 (2012), s. 1474-1481
    Number of pages8 s.
    Languageeng - English
    CountryUS - United States
    Keywordstooth ; apoptosis ; mineralisation
    Subject RIVFF - HEENT, Dentistry
    R&D ProjectsIAA600450904 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR)
    CEZAV0Z50450515 - UZFG-Y (2005-2011)
    UT WOS000312047200004
    DOI https://doi.org/10.1016/j.archoralbio.2012.06.009
    AnnotationObjectives: The primary enamel knot (PEK) is a population of cells that shows spatio-temporal restricted apoptosis during tooth development. It has been shown that caspase-9 and Apaf-1 are essential for apoptosis in the PEK as well as the central caspase-3. Caspase-7, as another executioner member in the caspase machinery, is considered to have caspase-3 like properties. Design: The aim of this study was to detect caspase-7 activation during molar tooth development with a special focus on the cells of the PEK and to correlate the expression with the pattern of apoptosis and caspase-3 activation. Apoptosis in the PEK was investigated in caspase-7 deficient mice to examine the functional consequence of loss of this specific caspase. In addition, odontoblasts and ameloblasts, which are known to undergo cell death during their secretory and maturation stages, were investigated. Results: Cleaved caspase-7 was found in the apoptotic region of the PEK, however, caspase-7-deficient mice still possessed apoptotic cells in the PEK in a similar distribution to the wild type. Caspase-7 is therefore not essential for apoptosis in the PEK. Notably, cleaved caspase-7-positive cells were found at later stages in odontoblasts and ameloblasts, but expression did not correlate with apoptosis in these tissues. Conclusions: The results indicate a non-essential apoptotic role of caspase-7 in the PEK apoptosis but suggest also possible non-apoptotic functions for caspase-7 in tooth development.
    WorkplaceInstitute of Animal Physiology and Genetics
    ContactJana Zásmětová, knihovna@iapg.cas.cz, Tel.: 315 639 554
    Year of Publishing2013
Number of the records: 1  

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