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Anticonvulsant action of GABA(B) receptor positive modulator CGP7930 in immature rats
- 1.0380617 - FGÚ 2013 RIV NL eng J - Journal Article
Mareš, Pavel
Anticonvulsant action of GABA(B) receptor positive modulator CGP7930 in immature rats.
Epilepsy Research. Roč. 100, 1-2 (2012), s. 49-54. ISSN 0920-1211. E-ISSN 1872-6844
R&D Projects: GA MŠMT(CZ) LC554; GA ČR(CZ) GAP304/10/1274
Institutional research plan: CEZ:AV0Z50110509
Keywords : GABA(B) receptors * cerebral cortex * epileptic afterdischarges * immature rats
Subject RIV: FH - Neurology
Impact factor: 2.241, year: 2012
Activation of GABA(B) receptors resulted in an anticonvulsant action in a model of cortical epileptic afterdischarges in three age groups of rats (12, 18 and 25 days old). Highest effect was seen in 12-day-old animals. The highest dose of CGP7930 used (40 mg/kg) compromised motor abilities of rats
Permanent Link: http://hdl.handle.net/11104/0211276
Number of the records: 1