Preservation of Metabolic Flexibility in Skeletal Muscle by a Combined Use of n-3 PUFA and Rosiglitazone in Dietary Obese Mice

0380295 - FGÚ 2013 RIV US eng J - Journal Article
Horáková, Olga - Medříková, Daša - van Schothorst, E. M. - Bunschoten, A. - Flachs, Pavel - Kůs, Vladimír - Kuda, Ondřej - Bardová, Kristina - Janovská, Petra - Hensler, Michal - Rossmeisl, Martin - Wang-Sattler, R. - Prehn, C. - Adamski, J. - Illig, T. - Keijer, J. - Kopecký, Jan
Preservation of Metabolic Flexibility in Skeletal Muscle by a Combined Use of n-3 PUFA and Rosiglitazone in Dietary Obese Mice.
PLoS ONE. Roč. 7, č. 8 (2012), e43764. ISSN 1932-6203. E-ISSN 1932-6203
R&D Projects: GA ČR(CZ) GA303/08/0664; GA MŠMT(CZ) 7E10059
Institutional support: RVO:67985823
Keywords : n-3 LC-PUFA * TZD * muscle insulin sensitivity
Subject RIV: FB - Endocrinology, Diabetology, Metabolism, Nutrition
Impact factor: 3.730, year: 2012

We investigated here whether n-3 LC-PUFA could elicit additive beneficial effects on metabolic flexibility when combined with a TZD drug rosiglitazone in mice. Metabolomic and gene expression analyses in the muscle suggested distinct and complementary effects of the interventions, with n-3 LC-PUFA supporting complete oxidation of fatty acids in mitochondria and the combination with n-3 LC-PUFA and rosiglitazone augmenting insulin sensitivity by the modulation of branched-chain amino acid metabolism. These beneficial metabolic effects were associated with the activation of the switch between glycolytic and oxidative muscle fibers, especially in mice fed combined diet of n-3 LC-PUFA and rosiglitazone
Permanent Link: http://hdl.handle.net/11104/0211036