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GCPII Variants, Paralogs and Orthologs
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SYSNO ASEP 0377922 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title GCPII Variants, Paralogs and Orthologs Author(s) Hlouchová, Klára (UOCHB-X) ORCID
Navrátil, Václav (UOCHB-X) RID, ORCID
Tykvart, Jan (UOCHB-X) RID, ORCID
Šácha, Pavel (UOCHB-X) RID, ORCID
Konvalinka, Jan (UOCHB-X) RID, ORCIDNumber of authors 5 Source Title Current Medicinal Chemistry. - : Bentham Science Publishers - ISSN 0929-8673
Roč. 19, č. 9 (2012), s. 1316-1322Number of pages 7 s. Language eng - English Country NL - Netherlands Keywords PSMA ; GCPIII ; NAALADase L ; splice variants ; homologs ; PSMAL Subject RIV CE - Biochemistry R&D Projects GAP304/12/0847 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z40550506 - UOCHB-X (2005-2011) UT WOS 000300641400009 DOI 10.2174/092986712799462676 Annotation Glutamate carboxypeptidase II (GCPII) and its splice variants, paralogs and human homologs represent a family of proteins with diverse tissue distribution, cellular localization and largely unknown function which have been explored only recently. While GCPII itself has been thoroughly studied from different perspectives, as clearly documented in this series of reviews, very little is known about other members of its family, even though they might be biologically relevant. Differential expression of individual GCPII splice variants is associated with tumor progression and prognosis of prostate cancer. The best studied GCPII homolog, GCPIII or NAALADase II, may be a valid pharmaceutical target for itself since it may compensate for a lack of normal GCPII enzymatic activity. Detailed molecular characterization of this family of proteins is thus very important not only with respect to the potential therapeutic use of GCPII inhibitors, but also for better understanding of the biological role of GCPII within as well as outside the nervous system. Workplace Institute of Organic Chemistry and Biochemistry Contact asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Jana Procházková, Tel.: 220 183 418 Year of Publishing 2013
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