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A metal-free DNA nuclease based on a cyclic peptide scaffold
- 1.0373403 - BFÚ 2012 RIV US eng J - Journal Article
Alkhader, S. - Ezra, A. - Kašpárková, Jana - Brabec, Viktor - Yavin, E.
A metal-free DNA nuclease based on a cyclic peptide scaffold.
Bioconjugate Chemistry. Roč. 21, č. 8 (2010), s. 1425-1431. ISSN 1043-1802. E-ISSN 1520-4812
R&D Projects: GA MŠMT(CZ) LC06030; GA AV ČR(CZ) KAN200200651
Keywords : DNA * cleavage * chemical nuclease
Subject RIV: BO - Biophysics
Impact factor: 5.002, year: 2010
This work describes DNA nuclease activity of conjugates composed of the cyclic peptide cyc-D-Lys-Gly-Arg-Ser-Arg conjugated to anthraquinone highlighting the various chemical features that are required for efficient DNA degradation by such metal-free DNA cutters.
Permanent Link: http://hdl.handle.net/11104/0206511
Number of the records: 1