Fmoc deprotection by tert-butylamine and its comparison in solution and solid phase synthesis
1.
SYSNO ASEP
0370529
Document Type
C - Proceedings Paper (int. conf.)
R&D Document Type
The record was not marked in the RIV
Title
Fmoc deprotection by tert-butylamine and its comparison in solution and solid phase synthesis
Author(s)
Flegel, Martin (UOCHB-X) Flegelová, Z. (CZ) Maloň, Petr (UOCHB-X) Klenerová, V. (CZ) Hynie, S. (CZ)
Number of authors
5
Source Title
Biologically Active Peptides. 12th Conference. - Praha : Institute of Organic Chemistry and Biochemistry AS CR, v. v. i, 2011 / Slaninová J.
- ISBN 978-80-86241-44-9
KAN200520703 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR)
KAN200100801 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR)
CEZ
AV0Z40550506 - UOCHB-X (2005-2011)
UT WOS
000393738100012
Annotation
tert-Butylamine was employed as the alternative to piperidine for Fmoc deprotection in liquid and solid phase peptide synthesis. Basic kinetic parameters of deprotecting reaction were checked in chosen Fmoc amino acid derivatives. Solid phase synthesis of cyclic part of oxytocin (tocinamide) was worked out and used for CD spectra measurement.
