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4'-Alkoxy oligodeoxynucleotides: a novel class of RNA mimics
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SYSNO ASEP 0369807 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title 4'-Alkoxy oligodeoxynucleotides: a novel class of RNA mimics Author(s) Liboska, Radek (UOCHB-X) RID, ORCID
Snášel, Jan (UOCHB-X) RID
Barvík, I. (CZ)
Buděšínský, Miloš (UOCHB-X) RID, ORCID
Pohl, Radek (UOCHB-X) RID, ORCID
Točík, Zdeněk (UOCHB-X)
Páv, Ondřej (UOCHB-X) RID, ORCID
Rejman, Dominik (UOCHB-X) RID, ORCID
Novák, Pavel (UOCHB-X)
Rosenberg, Ivan (UOCHB-X) RID, ORCIDNumber of authors 10 Source Title Organic & Biomolecular Chemistry. - : Royal Society of Chemistry - ISSN 1477-0520
Roč. 9, č. 24 (2011), s. 8261-8267Number of pages 7 s. Language eng - English Country GB - United Kingdom Keywords 4'-alkoxy oligothymidylates ; modified oligonucleotides ; oligonucleotide hybridisation ; RNA mimics Subject RIV CC - Organic Chemistry R&D Projects GA202/09/0193 GA ČR - Czech Science Foundation (CSF) KAN200520801 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) LC06061 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) CEZ AV0Z40550506 - UOCHB-X (2005-2011) UT WOS 000297354100008 DOI 10.1039/c1ob06148h Annotation 4´-Alkoxy-oligothymidylates were prepared as model compounds to study the influence of a C4´-alkoxy group on hybridisation. The phosphodiester homooligomers (15 units long) containing either a 4´-methoxy or 4´-(2-methoxyethoxy) group were found to display increased hybridisation with both dA15 and rA15 complementary counterparts compared to the natural oligothymidylate. In addition, their hybridisation behaviour was found to be similar to that of the regioisomeric 2´-O-methyl-oligothymidylate. The 4´-alkoxy modified nucleotides seem to be promising compounds for assembly of chimeric oligonucleotides with tunable properties. Workplace Institute of Organic Chemistry and Biochemistry Contact asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Jana Procházková, Tel.: 220 183 418 Year of Publishing 2012
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