Number of the records: 1  

4'-Alkoxy oligodeoxynucleotides: a novel class of RNA mimics

  1. 1.
    SYSNO ASEP0369807
    Document TypeJ - Journal Article
    R&D Document TypeJournal Article
    Subsidiary JČlánek ve WOS
    Title4'-Alkoxy oligodeoxynucleotides: a novel class of RNA mimics
    Author(s) Liboska, Radek (UOCHB-X) RID, ORCID
    Snášel, Jan (UOCHB-X) RID
    Barvík, I. (CZ)
    Buděšínský, Miloš (UOCHB-X) RID, ORCID
    Pohl, Radek (UOCHB-X) RID, ORCID
    Točík, Zdeněk (UOCHB-X)
    Páv, Ondřej (UOCHB-X) RID, ORCID
    Rejman, Dominik (UOCHB-X) RID, ORCID
    Novák, Pavel (UOCHB-X)
    Rosenberg, Ivan (UOCHB-X) RID, ORCID
    Number of authors10
    Source TitleOrganic & Biomolecular Chemistry. - : Royal Society of Chemistry - ISSN 1477-0520
    Roč. 9, č. 24 (2011), s. 8261-8267
    Number of pages7 s.
    Languageeng - English
    CountryGB - United Kingdom
    Keywords4'-alkoxy oligothymidylates ; modified oligonucleotides ; oligonucleotide hybridisation ; RNA mimics
    Subject RIVCC - Organic Chemistry
    R&D ProjectsGA202/09/0193 GA ČR - Czech Science Foundation (CSF)
    KAN200520801 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR)
    LC06061 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
    CEZAV0Z40550506 - UOCHB-X (2005-2011)
    UT WOS000297354100008
    DOI10.1039/c1ob06148h
    Annotation4´-Alkoxy-oligothymidylates were prepared as model compounds to study the influence of a C4´-alkoxy group on hybridisation. The phosphodiester homooligomers (15 units long) containing either a 4´-methoxy or 4´-(2-methoxyethoxy) group were found to display increased hybridisation with both dA15 and rA15 complementary counterparts compared to the natural oligothymidylate. In addition, their hybridisation behaviour was found to be similar to that of the regioisomeric 2´-O-methyl-oligothymidylate. The 4´-alkoxy modified nucleotides seem to be promising compounds for assembly of chimeric oligonucleotides with tunable properties.
    WorkplaceInstitute of Organic Chemistry and Biochemistry
    Contactasep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Jana Procházková, Tel.: 220 183 418
    Year of Publishing2012
Number of the records: 1  

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