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pH-sensitive polymeric conjugates of an anthracycline cancerostatic drug for targeted therapy
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SYSNO ASEP 0369686 Document Type P - Patent R&D Document Type The record was not marked in the RIV Title pH-sensitive polymeric conjugates of an anthracycline cancerostatic drug for targeted therapy Author(s) Ulbrich, Karel (UMCH-V) RID
Etrych, Tomáš (UMCH-V) RID, ORCID
Říhová, Blanka (MBU-M) RID
Jelínková, Markéta (MBU-M)
Kovář, Marek (MBU-M) RID, ORCIDYear of issue 2011 Patent no. or utility model no. or industrial design no. US7919076 Date of the patent acceptance 05.04.2011 Name of the patent owner Zentiva, k. s Language eng - English Country US - United States Keywords cancerostatics ; polymer cojugates ; targeted therapy Subject RIV CC - Organic Chemistry CEZ AV0Z40500505 - UMCH-V (2005-2011) AV0Z50200510 - MBU-M (2005-2011) Annotation Conjugates consisting of a polymeric carrier constituted by 30 to 3,000 monomer units linked to form a polymeric chain, composed of a) 60 to 99% of N-(2-hydroxypropyl)methacrylamide units, b) 1 to 25% of units of methacryloylated hydrazones of .alpha.-amino acids, .epsilon.-amino acids, aromatic amino acids or oligopeptides terminated with a molecule of an anthracycline cancerostatic, c) 0.5 to 15% of units of methacryloylated .alpha.-amino acids, .epsilon.-amino acids, aromatic amino acids or oligopeptides or their sodium salts. Workplace Institute of Macromolecular Chemistry Contact Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Year of Publishing 2012
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