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Efficient synthesis and biological properties of the 2‘-trifluoromethyl analogues of acyclic nucleosides and acyclic nucleoside phosphonates
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SYSNO ASEP 0369214 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Efficient synthesis and biological properties of the 2‘-trifluoromethyl analogues of acyclic nucleosides and acyclic nucleoside phosphonates Author(s) Jansa, Petr (UOCHB-X) RID
Kolman, Viktor (UOCHB-X) RID
Kostinová, Alexandra (UOCHB-X)
Dračínský, Martin (UOCHB-X) RID, ORCID
Mertlíková-Kaiserová, Helena (UOCHB-X) RID, ORCID
Janeba, Zlatko (UOCHB-X) RID, ORCIDNumber of authors 6 Source Title Collection of Czechoslovak Chemical Communications. - : Ústav organické chemie a biochemie AV ČR, v. v. i. - ISSN 0010-0765
Roč. 76, č. 10 (2011), s. 1187-1198Number of pages 12 s. Language eng - English Country CZ - Czech Republic Keywords nucleosides ; nucleotides ; phosphorus ; fluorine ; biological activity ; antibiotics Subject RIV CC - Organic Chemistry R&D Projects VG20102015046 GA MV - Ministry of Interior (MV) CEZ AV0Z40550506 - UOCHB-X (2005-2011) UT WOS 000298004400003 DOI 10.1135/cccc2011105 Annotation Efficient synthesis of acyclic nucleosides and acyclic nucleoside phosphonates substituted at the C-2′ position of the aliphatic part by the trifluoromethyl group is described, starting from trifluoromethyloxirane. None of the prepared compounds exhibit any antiviral, antiproliferative or anti-toxin activities. Workplace Institute of Organic Chemistry and Biochemistry Contact asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Jana Procházková, Tel.: 220 183 418 Year of Publishing 2012
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