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Transplantation of Predifferentiated Adipose-Derived Stromal Cells for the Treatment of Spinal Cord Injury
- 1.0366090 - ÚEM 2012 RIV US eng J - Journal Article
Arboleda Toro, David - Forostyak, Serhiy - Jendelová, Pavla - Mareková, Dana - Amemori, Takashi - Pivoňková, Helena - Mašínová, Katarína - Syková, Eva
Transplantation of Predifferentiated Adipose-Derived Stromal Cells for the Treatment of Spinal Cord Injury.
Cellular and Molecular Neurobiology. Roč. 31, č. 7 (2011), s. 1113-1122. ISSN 0272-4340. E-ISSN 1573-6830
R&D Projects: GA ČR GA305/09/0717; GA AV ČR IAA500390902
Grant - others:GA MŠk.(CZ) 1M0538; GA ČR(CZ) GD309/08/H079; GA ČR(CZ) GAP304/10/0320
Program: 1M
Institutional research plan: CEZ:AV0Z50390512; CEZ:AV0Z50390703
Keywords : Adipose tissue * Differentiation * Mesenchymal stromal cells
Subject RIV: FH - Neurology
Impact factor: 1.969, year: 2011
The purpose of the study was to compare predifferentiated ASCs (pASCs) with naïve ASCs in vitro and after transplantation into rats with a balloon-induced spinal cord compression lesion. ASC spheres were induced prior to transplantation, then pASCs or ASCs were injected intraspinally. Behavioral, histological and electrophysiological methods were used to assess the cells' fate and the rats' functional outcome.The predifferentiation of ASCs facilitated the protection of denuded axons; however, functional improvement was comparable in both groups, indicating that repair was induced mainly through paracrine mechanisms.
Permanent Link: http://hdl.handle.net/11104/0201181
Number of the records: 1