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Relation of genetic phylogeny and geographical distance of tick-borne encephalitis virus in central Europe
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SYSNO ASEP 0364901 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Relation of genetic phylogeny and geographical distance of tick-borne encephalitis virus in central Europe Author(s) Weidmann, M. (NL)
Růžek, Daniel (BC-A) RID, ORCID
Křivanec, K. (CZ)
Zoeller, G. (DE)
Essbauer, S. (DE)
Pfeffer, M. (DE)
Zanotto, P. M. de A. (BR)
Hufert, F.T. (NL)
Dobler, G. (DE)Source Title Journal of General Virology. - : Microbiology Society - ISSN 0022-1317
Roč. 92, Part 8 (2011), 1906-1916Number of pages 11 s. Language eng - English Country GB - United Kingdom Keywords IXODES-RICINUS ; NATURAL FOCI ; ROE DEER ; ENDEMIC AREA ; RUSSIA ; FLAVIVIRUSES ; EVOLUTION ; VECTOR ; SWEDEN ; JAPAN Subject RIV EE - Microbiology, Virology R&D Projects GPP302/10/P438 GA ČR - Czech Science Foundation (CSF) GAP502/11/2116 GA ČR - Czech Science Foundation (CSF) LC06009 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) CEZ AV0Z60220518 - PAU-O, BC-A (2005-2011) UT WOS 000293488800020 DOI 10.1099/vir.0.032417-0 Annotation Tick-borne encephalitis virus (TBEV) is the most important arboviral agent causing disease of the central nervous system in central Europe. In this study, 61 TBEV E gene sequences derived from 48 isolates from the Czech Republic (CR), and 4 isolates and 9 TBEV strains detected in ticks from Germany (1954 to 2009), were sequenced and subjected to phylogenetic and Bayesian phylodynamic. The general Eurasian continental east-to-west pattern of the spread of TBEV was confirmed at the regional level but is interlaced with spreading that arises because of local geography and anthropogenic influence. This spread is reflected by the disease pattern in the CR that has been observed since 1991. The overall evolutionary rate was estimated to be approximately 8x10(-4) substitutions per nucleotide per year. The analysis of the TBEV E genes of 11 strains isolated at one natural focus in Zd'ar Kaplice proved for the first time that TBEV is indeed subject to local evolution. Workplace Biology Centre (since 2006) Contact Dana Hypšová, eje@eje.cz, Tel.: 387 775 214 Year of Publishing 2012
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