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Cellular and behavioural effects of a new steroidal inhibitor of the N-methyl-d-aspartate receptor 3α5β-pregnanolone glutamate
- 1.0364480 - FGÚ 2012 RIV NL eng J - Journal Article
Rambousek, Lukáš - Bubeníková-Valešová, V. - Kačer, P. - Syslová, K. - Kenney, Jana - Holubová, Kristína - Najmanová, V. - Zach, P. - Svoboda, Jan - Stuchlík, Aleš - Chodounská, Hana - Kapras, Vojtěch - Adamusová, Eva - Borovská, Jiřina - Vyklický ml., Ladislav - Valeš, Karel
Cellular and behavioural effects of a new steroidal inhibitor of the N-methyl-d-aspartate receptor 3α5β-pregnanolone glutamate.
Neuropharmacology. Roč. 61, 1-2 (2011), s. 61-68. ISSN 0028-3908. E-ISSN 1873-7064
R&D Projects: GA MZd(CZ) NS10365; GA MZd(CZ) NR9180; GA ČR(CZ) GA309/07/0271; GA ČR(CZ) GA203/08/1498; GA ČR(CZ) GA309/09/0286; GA MŠMT(CZ) 1M0517; GA MŠMT(CZ) LC554
Grant - others:EC(XE) LSMH-CT-2007-037765
Institutional research plan: CEZ:AV0Z50110509; CEZ:AV0Z40550506
Keywords : neuroactive steroid * NMDA * neuroprotectivity
Subject RIV: FH - Neurology
Impact factor: 4.814, year: 2011
The results show that 3alfa5betaPregnanolone glutamate, use-dependent NMDA antagonist, is able to cross the blood brain barrier, does not induce psychotomimetic symptoms (such as hyperlocomotion and sensorimotor gating deficit) and reduced an excitotoxic damage of brain tissue and subsequent behavioural impairment in rats
Permanent Link: http://hdl.handle.net/11104/0199958
Number of the records: 1