Synthesis of new potential inhibitors of 5´-nucleotidases

0361550 - ÚOCHB 2012 CZ eng C - Conference Paper (international conference)
Šimák, Ondřej - Pachl, Petr - Brynda, Jiří - Rosenberg, Ivan
Synthesis of new potential inhibitors of 5´-nucleotidases.
Chemistry of Nucleic Acid Components. 15th Symposium. Praha: Institute of Organic Chemistry and Biochemistry AS CR, v. v. i., 2011 - (Hocek, M.), s. 462-464. Collection Symposium Series, 12. ISBN 978-80-86241-37-1.
[Chemistry of Nucleic Acid Components /15./. Český Krumlov (CZ), 05.06.2011-10.06.2011]
R&D Projects: GA ČR GA203/09/0820; GA AV ČR KAN200520801; GA MŠMT(CZ) LC06077
Institutional research plan: CEZ:AV0Z40550506; CEZ:AV0Z50520514
Keywords : nucleotide analogs * phosphonobenzylidene ring * potential 5´-nucleotidase inhibitors * phosphonate nucleotides
Subject RIV: CC - Organic Chemistry

The work deals with the synthesis of potential inhibitors of 5´-nucleotidases. The phosphonobenzylidene ring of a phosphonate nucleotide derivative was recognized as a target for proposed synthetic modifications. Substituents selected on the basis of a docking study, mostly the electronegative ones, should be suitable for the formation of additional hydrogen bonds, and thus the increased inhibition of the enzymes.
Permanent Link: http://hdl.handle.net/11104/0198844