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Azido analogs of neuroactive steroids
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SYSNO ASEP 0361126 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Azido analogs of neuroactive steroids Author(s) Vidrna, Lukáš (UOCHB-X)
Černý, Ivan (UOCHB-X)
Pouzar, Vladimír (UOCHB-X)
Borovská, Jiřina (FGU-C)
Vyklický, Vojtěch (FGU-C) RID, ORCID, SAI
Vyklický ml., Ladislav (FGU-C) RID, ORCID, SAI
Chodounská, Hana (UOCHB-X) RID, ORCIDNumber of authors 7 Source Title Steroids. - : Elsevier - ISSN 0039-128X
Roč. 76, 10/11 (2011), s. 1043-1050Number of pages 8 s. Language eng - English Country US - United States Keywords neuroactive steroids ; synthesis ; azides ; NMDA receptor Subject RIV CC - Organic Chemistry R&D Projects LC06077 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) LC554 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) GA203/08/1498 GA ČR - Czech Science Foundation (CSF) GA309/07/0271 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z40550506 - UOCHB-X (2005-2011) AV0Z50110509 - FGU-C (2005-2011) UT WOS 000294074700014 DOI 10.1016/j.steroids.2011.04.008 Annotation Analogs of neurosteroid pregnanolone, modified in position 17 were prepared. Compounds with 20-keto pregnane side chain replaced completely or only partially by azide were synthesized and converted into corresponding sulfates. Tests for inhibition of glutamate induced response on NMDA receptors revealed retaining of the activity in some extent, three of sulfates tested were more active than parent compound. Workplace Institute of Organic Chemistry and Biochemistry Contact asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Jana Procházková, Tel.: 220 183 418 Year of Publishing 2012
Number of the records: 1