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Precursors and formation of pyrithione and other pyridyl-containing sulfur compounds in drumstick onion, Allium stipitatum
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SYSNO ASEP 0359831 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Precursors and formation of pyrithione and other pyridyl-containing sulfur compounds in drumstick onion, Allium stipitatum Author(s) Kubec, R. (CZ)
Krejčová, P. (CZ)
Šimek, Petr (BC-A) RID, ORCID
Václavík, L. (CZ)
Hajšlová, J. (CZ)
Schraml, Jan (UCHP-M) RID, ORCID, SAINumber of authors 6 Source Title Journal of Agricultural and Food Chemistry. - : American Chemical Society - ISSN 0021-8561
Roč. 59, č. 10 (2011), s. 5763-5770Number of pages 8 s. Language eng - English Country US - United States Keywords Allium stipitatum ; S-(2-pyridyl)cysteine N-oxide ; marasmin Subject RIV CE - Biochemistry R&D Projects IAA400720706 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) CEZ AV0Z50070508 - ENTU-I, BC-A (2005-2011) AV0Z40720504 - UCHP-M (2005-2011) UT WOS 000290691300076 DOI Annotation Two novel, cysteine derivatives were isolated from the bulbs of Allium stipitatum (Allium sub) and shown to be S-(2-pyridyl)cysteine N-oxide and S-(2-pyridyl) glutathione N-oxide. The former compound is the first example of a naturally occurring alliinase substrate that contains an N-oxide functionality instead of the S-oxide group. In addition, S-methylcysteine S-oxide (methiin) and S-methyl thiomethyl)cysteine 4-oxide (marasmin) were found in the bulbs. The alliinase-mediated formation of pyridyl-containing compounds following disruption of A. stipitatum bulbs was studied by a combination of HPLC-MS, HPLC-PDA, DART-MS, and NMR techniques. No pyridyl-containing thiosulfinates are present in homogenized bulbs. Instead, various pyridine N-oxides such as N-hydroxypyridine-2(1H)-thione (pyrithione), 2-(methyldithio)pyridine N-oxide, 2-(methylthio) methyldithio]pyridine N-oxide, di(2-pyridyl) disulfide N-oxide, and di(2-pyridyl) disulfide N,N0-dioxide are reported. Workplace Biology Centre (since 2006) Contact Dana Hypšová, eje@eje.cz, Tel.: 387 775 214 Year of Publishing 2012
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