Number of the records: 1  

Biodegradable star HPMA polymer conjugates of doxorubicin for passive tumor targeting

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    SYSNO ASEP0359227
    Document TypeJ - Journal Article
    R&D Document TypeJournal Article
    Subsidiary JČlánek ve WOS
    TitleBiodegradable star HPMA polymer conjugates of doxorubicin for passive tumor targeting
    Author(s) Etrych, Tomáš (UMCH-V) RID, ORCID
    Strohalm, Jiří (UMCH-V)
    Chytil, Petr (UMCH-V) RID, ORCID
    Černoch, Peter (UMCH-V) RID, ORCID
    Starovoytova, Larisa (UMCH-V) RID
    Pechar, Michal (UMCH-V) RID, ORCID
    Ulbrich, Karel (UMCH-V) RID
    Source TitleEuropean Journal of Pharmaceutical Sciences. - : Elsevier - ISSN 0928-0987
    Roč. 42, č. 5 (2011), s. 527-539
    Number of pages13 s.
    Languageeng - English
    CountryNL - Netherlands
    Keywordsdendrimer ; HPMA copolymers ; doxorubicin
    Subject RIVCD - Macromolecular Chemistry
    R&D ProjectsIAA400500806 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR)
    IAAX00500803 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR)
    GA203/08/0543 GA ČR - Czech Science Foundation (CSF)
    CEZAV0Z40500505 - UMCH-V (2005-2011)
    UT WOS000290822800012
    DOI10.1016/j.ejps.2011.03.001
    AnnotationNew biodegradable star polymer–doxorubicin conjugates designed for passive tumor targeting were investigated and the present study described their synthesis, physico-chemical characterization, drug release and biodegradation. In the conjugates the core formed by poly(amido amine) dendrimers was grafted with semitelechelic N-(2-hydroxypropyl)methacrylamide copolymers bearing doxorubicin attached by hydrazone bonds, which enabled intracellular pH-controlled drug release, or by a GFLG sequence, which was susceptible to enzymatic degradation. The controlled synthesis utilizing semitelechelic copolymer precursors facilitated preparation of biodegradable polymer conjugates in a broad range of molecular weights (110–295 kD). The polymer grafts were attached to the dendrimers either through stable amide bonds or enzymatically or reductively degradable spacers, which enabled intracellular degradation of the HMW polymer carrier to products that were able to be excreted by glomerular filtration.
    WorkplaceInstitute of Macromolecular Chemistry
    ContactEva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358
    Year of Publishing2012
Number of the records: 1  

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