Number of the records: 1
Biodegradable star HPMA polymer conjugates of doxorubicin for passive tumor targeting
- 1.
SYSNO ASEP 0359227 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Biodegradable star HPMA polymer conjugates of doxorubicin for passive tumor targeting Author(s) Etrych, Tomáš (UMCH-V) RID, ORCID
Strohalm, Jiří (UMCH-V)
Chytil, Petr (UMCH-V) RID, ORCID
Černoch, Peter (UMCH-V) RID, ORCID
Starovoytova, Larisa (UMCH-V) RID
Pechar, Michal (UMCH-V) RID, ORCID
Ulbrich, Karel (UMCH-V) RIDSource Title European Journal of Pharmaceutical Sciences. - : Elsevier - ISSN 0928-0987
Roč. 42, č. 5 (2011), s. 527-539Number of pages 13 s. Language eng - English Country NL - Netherlands Keywords dendrimer ; HPMA copolymers ; doxorubicin Subject RIV CD - Macromolecular Chemistry R&D Projects IAA400500806 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) IAAX00500803 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) GA203/08/0543 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z40500505 - UMCH-V (2005-2011) UT WOS 000290822800012 DOI 10.1016/j.ejps.2011.03.001 Annotation New biodegradable star polymer–doxorubicin conjugates designed for passive tumor targeting were investigated and the present study described their synthesis, physico-chemical characterization, drug release and biodegradation. In the conjugates the core formed by poly(amido amine) dendrimers was grafted with semitelechelic N-(2-hydroxypropyl)methacrylamide copolymers bearing doxorubicin attached by hydrazone bonds, which enabled intracellular pH-controlled drug release, or by a GFLG sequence, which was susceptible to enzymatic degradation. The controlled synthesis utilizing semitelechelic copolymer precursors facilitated preparation of biodegradable polymer conjugates in a broad range of molecular weights (110–295 kD). The polymer grafts were attached to the dendrimers either through stable amide bonds or enzymatically or reductively degradable spacers, which enabled intracellular degradation of the HMW polymer carrier to products that were able to be excreted by glomerular filtration. Workplace Institute of Macromolecular Chemistry Contact Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Year of Publishing 2012
Number of the records: 1