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Biodegradable star HPMA polymer conjugates of doxorubicin for passive tumor targeting
- 1.0359227 - ÚMCH 2012 RIV NL eng J - Journal Article
Etrych, Tomáš - Strohalm, Jiří - Chytil, Petr - Černoch, Peter - Starovoytova, Larisa - Pechar, Michal - Ulbrich, Karel
Biodegradable star HPMA polymer conjugates of doxorubicin for passive tumor targeting.
European Journal of Pharmaceutical Sciences. Roč. 42, č. 5 (2011), s. 527-539. ISSN 0928-0987. E-ISSN 1879-0720
R&D Projects: GA AV ČR IAA400500806; GA AV ČR IAAX00500803; GA ČR GA203/08/0543
Institutional research plan: CEZ:AV0Z40500505
Keywords : dendrimer * HPMA copolymers * doxorubicin
Subject RIV: CD - Macromolecular Chemistry
Impact factor: 3.212, year: 2011
New biodegradable star polymer–doxorubicin conjugates designed for passive tumor targeting were investigated and the present study described their synthesis, physico-chemical characterization, drug release and biodegradation. In the conjugates the core formed by poly(amido amine) dendrimers was grafted with semitelechelic N-(2-hydroxypropyl)methacrylamide copolymers bearing doxorubicin attached by hydrazone bonds, which enabled intracellular pH-controlled drug release, or by a GFLG sequence, which was susceptible to enzymatic degradation. The controlled synthesis utilizing semitelechelic copolymer precursors facilitated preparation of biodegradable polymer conjugates in a broad range of molecular weights (110–295 kD). The polymer grafts were attached to the dendrimers either through stable amide bonds or enzymatically or reductively degradable spacers, which enabled intracellular degradation of the HMW polymer carrier to products that were able to be excreted by glomerular filtration.
Permanent Link: http://hdl.handle.net/11104/0006435
Number of the records: 1