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Conjugates of doxorubicin with graft HPMA copolymers for passive tumor targeting
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SYSNO ASEP 0359074 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Conjugates of doxorubicin with graft HPMA copolymers for passive tumor targeting Title Roubované polymerní konjugáty s doxorubicinem pro pasivní směrování do nádorů Author(s) Etrych, Tomáš (UMCH-V) RID, ORCID
Chytil, Petr (UMCH-V) RID, ORCID
Mrkvan, Tomáš (MBU-M)
Šírová, Milada (MBU-M) RID, ORCID
Říhová, Blanka (MBU-M) RID
Ulbrich, Karel (UMCH-V) RIDSource Title Journal of Controlled Release. - : Elsevier - ISSN 0168-3659
Roč. 132, č. 3 (2008), s. 184-192Number of pages 9 s. Language eng - English Country NL - Netherlands Keywords HPMA copolymers ; drug carriers ; doxorubicin ; graft polymers Subject RIV CE - Biochemistry R&D Projects FI-IM2/111 GA MPO - Ministry of Industry and Trade (MPO) UT WOS 000261902800006 DOI 10.1016/j.jconrel.2008.04.017 Annotation Synthesis, physicochemical characterisation and preliminary evaluation of biological properties of a new graft high-molecular weight polymer–doxorubicin conjugate designed for solid tumor treatment have been described. Three types of the conjugate differing in detailed structure of the biodegradable spacer between the polymer grafts and main polymer chain were synthesized by grafting the reactive semitelechelic copolymer precursors onto the main chain of multivalent HPMA copolymer. Workplace Institute of Macromolecular Chemistry Contact Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Year of Publishing 2011
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