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The effect of lipid peroxidation products on reactive oxygen species formation and nitric oxide production in lipopolysaccharide-stimulated RAW 264.7 macrophages
- 1.0358792 - BFÚ 2012 RIV GB eng J - Journal Article
Ambrožová, Gabriela - Pekarová, Michaela - Lojek, Antonín
The effect of lipid peroxidation products on reactive oxygen species formation and nitric oxide production in lipopolysaccharide-stimulated RAW 264.7 macrophages.
Toxicology in Vitro. Roč. 25, č. 1 (2011), s. 145-152. ISSN 0887-2333. E-ISSN 1879-3177
R&D Projects: GA MŠMT(CZ) OC08058; GA ČR(CZ) GA524/08/1753
Institutional research plan: CEZ:AV0Z50040507; CEZ:AV0Z50040702
Keywords : lipid peroxidation products * reactive oxygen species * nitric oxide
Subject RIV: BO - Biophysics
Impact factor: 2.775, year: 2011
The aim of the present study was to investigate the effects of lipid peroxidation products (LPPs) - acrolein, 4-hydroxynonenal, and malondialdehyde - on ROS and NO production in RAW 264.7 macrophages. Our study shows that the cytotoxic action of acrolein and 4-hydroxynonenal works in a dose- and timedependent manner. Moreover, LPPs can inhibit ROS and NO production partially independently of their toxic effect. Changes in enzymatic pathways and NO scavenging properties are included in the downregulation of reactive species formation.
Permanent Link: http://hdl.handle.net/11104/0196729
Number of the records: 1