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Pharmacological Evaluation of the Long-Term Effects of Xanomeline on the M1 Muscarinic Acetylcholine Receptor
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SYSNO ASEP 0355377 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Pharmacological Evaluation of the Long-Term Effects of Xanomeline on the M1 Muscarinic Acetylcholine Receptor Author(s) Grant, M.K.O. (US)
Noetzel, M.J. (US)
De Lorme, K.C. (US)
Jakubík, Jan (FGU-C) RID, ORCID
Doležal, Vladimír (FGU-C) RID, ORCID
El-Fakahany, E. E. (US)Source Title PLoS ONE. - : Public Library of Science - ISSN 1932-6203
Roč. 5, č. 12 (2010), e15722-16Number of pages 16 s. Language eng - English Country US - United States Keywords Xanomeline ; muscarinic acetylcholine receptor Subject RIV CE - Biochemistry R&D Projects GA305/09/0681 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z50110509 - FGU-C (2005-2011) UT WOS 000285579200032 DOI 10.1371/journal.pone.0015722 Annotation Additional data indicated that blockade of the receptor orthosteric site or the use of a non-functional receptor mutant reversed the long-term effects of xanomeline, but not its persistent binding at an allosteric site. Furthemore, the long-term effects of xanomeline on the receptor are mainly due to receptor down-regulation rather than internalization Workplace Institute of Physiology Contact Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Year of Publishing 2011
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