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Changes in Cell Adhesivity and Cytoskeleton-Related Proteins During Imatinib-Induced Apoptosis of Leukemic JURL-MK1 Cells
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SYSNO ASEP 0354386 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Changes in Cell Adhesivity and Cytoskeleton-Related Proteins During Imatinib-Induced Apoptosis of Leukemic JURL-MK1 Cells Author(s) Kuželová, K. (CZ)
Pluskalová, M. (CZ)
Grebeňová, D. (CZ)
Pavlásková, Kateřina (MBU-M)
Halada, Petr (MBU-M) RID, ORCID
Hrkal, Z. (CZ)Source Title Journal of Cellular Biochemistry. - : Wiley - ISSN 0730-2312
Roč. 111, č. 6 (2010), s. 1413-1425Number of pages 13 s. Language eng - English Country US - United States Keywords imatinib ; adhesion ; cytoskeleton Subject RIV CE - Biochemistry R&D Projects LC07017 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) NR9243 GA MZd - Ministry of Health (MZ) CEZ AV0Z50200510 - MBU-M (2005-2011) UT WOS 000286300700004 DOI 10.1002/jch.22868 Annotation The fusion protein Bcr–Abl, which is the molecular cause of chronic myelogenous leukemia (CML) interacts in multiple points with signaling pathways regulating the cellular adhesivity and cytoskeleton architecture and dynamics. We explored the effects of imatinib mesylate, an inhibitor of Bcr–Abl protein used in front-line CML therapy, on the adhesivity of JURL-MK1 cells to fibronectin and searched for underlying changes in the cell proteome. As imatinib induces apoptosis of JURL-MK1 cells, we used three different caspase inhibitors to discriminate between direct consequences of Bcr–Abl inhibition and secondary changes related to the apoptosis. Imatinib treatment caused a transient increase in JURL-MK1 cell adhesivity to fibronectin, possibly due to the switch off of Bcr–Abl activity Workplace Institute of Microbiology Contact Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231 Year of Publishing 2011
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