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Alterations of NO synthase isoforms in brain and kidney of rats with genetic and salt hypertension
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SYSNO ASEP 0353982 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Alterations of NO synthase isoforms in brain and kidney of rats with genetic and salt hypertension Author(s) Hojná, Silvie (FGU-C) RID, ORCID
Kuneš, Jaroslav (FGU-C) RID, ORCID
Zicha, Josef (FGU-C) RID, ORCID, SAISource Title Physiological Research. - : Fyziologický ústav AV ČR, v. v. i. - ISSN 0862-8408
Roč. 59, č. 6 (2010), s. 997-1009Number of pages 13 s. Language eng - English Country CZ - Czech Republic Keywords brainstem ; diencephalon ; kidney Subject RIV ED - Physiology R&D Projects 1M0510 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) GA305/08/0139 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z50110509 - FGU-C (2005-2011) UT WOS 000285711400018 Annotation Our study evaluated NO synthase (NOS) activity and protein expression of its three isoforms - neuronal (nNOS), endothelial NOS (eNOS) and inducible (iNOS) - in two brain regions involved in blood pressure control (diencephalon and brainstem) as well as in the kidney of rats with either genetic (SHR) or salt-induced hypertension (Dahl rats). We disclosed similar changes of NO system in the brainstem (but not in the diencephalon) of rats with genetic and salt-induced hypertension. Decreased nNOS expression was associated with increased blood pressure due to enhanced sympathetic tone Workplace Institute of Physiology Contact Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Year of Publishing 2011
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