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Fibrin/Hyaluronic Acid Composite Hydrogels as Appropriate Scaffolds for In Vivo Artificial Cartilage Implantation
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SYSNO ASEP 0351847 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Fibrin/Hyaluronic Acid Composite Hydrogels as Appropriate Scaffolds for In Vivo Artificial Cartilage Implantation Author(s) Rampichová, Michala (UEM-P) RID, ORCID
Filová, Eva (UEM-P) RID, ORCID
Varga, F. (CZ)
Lytvynets, Andriy (UEM-P)
Prosecká, Eva (UEM-P)
Koláčná, Lucie (UEM-P)
Motlík, Jan (UZFG-Y) RID, ORCID
Nečas, A. (CZ)
Vajner, L. (CZ)
Uhlík, J. (CZ)
Amler, Evžen (UEM-P) RIDSource Title Asaio Journal - ISSN 1058-2916
Roč. 56, č. 6 (2010), s. 563-568Number of pages 6 s. Language eng - English Country US - United States Keywords chondrocyte ; composite scaffold ; osteochondral defect regeneration Subject RIV BO - Biophysics R&D Projects GAP304/10/1307 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z50390512 - UEM-P (2005-2011) AV0Z50390703 - UEM-P (2007-2013) AV0Z50450515 - UZFG-Y (2005-2011) UT WOS 000283719600014 DOI 10.1097/MAT.0b013e3181fcbe24 Annotation Hydrogels prepared from a mixture of fibrin and high-molecular weight (MW) hyaluronic acid (HA) were found to be suitable scaffolds for chondrocyte seeding and pig knee cartilage regeneration. Collagen in the hydrogels is not necessary for the formation of biomechanically stable tissue. Regenerated cartilage showed very good biomechanical and histological properties only 6 months after implantation. Notably, the quality of the healing process was dependent on the initial chondrocyte concentration of the scaffolds. These experiments were performed according to good laboratory practice (GLP). Workplace Institute of Experimental Medicine Contact Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Year of Publishing 2011
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