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Negative regulation of Wnt signaling mediated by CK1-phosphorylated Dishevelled via Ror2
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SYSNO ASEP 0351205 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Negative regulation of Wnt signaling mediated by CK1-phosphorylated Dishevelled via Ror2 Author(s) Witte, F. (DE)
Bernatík, O. (CZ)
Kirchner, K. (DE)
Mašek, J. (CZ)
Mahl, A. (DE)
Krejčí, P. (CZ)
Mundlos, S. (DE)
Schambony, A. (DE)
Bryja, Vítězslav (BFU-R) RID, ORCID
Stricker, S. (DE)Number of authors 10 Source Title FASEB Journal. - : Wiley - ISSN 0892-6638
Roč. 24, č. 7 (2010), s. 2417-2426Number of pages 10 s. Language eng - English Country US - United States Keywords Wnt/beta-catenin signaling ; casein kinase ; Ror2 Subject RIV BO - Biophysics R&D Projects GC204/09/J030 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z50040507 - BFU-R (2005-2011) AV0Z50040702 - BFU-R (2007-2013) UT WOS 000279343600028 DOI 10.1096/fj.09-150615 Annotation Dishevelled (Dvl) is a multifunctional effector of different Wnt cascades. We provide evidence that Dvl phosphorylated by casein kinase 1 epsilon can bind atypical receptor kinase Ror2. We show that CK1-phosphorylated Dvl induced by both canonical and non-canonical Wnt ligands triggers negative feedback regulation in a Ror2-dependent manner. Workplace Institute of Biophysics Contact Jana Poláková, polakova@ibp.cz, Tel.: 541 517 244 Year of Publishing 2011
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