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Astrocytes in Alzheimer's Disease
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SYSNO ASEP 0349472 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Astrocytes in Alzheimer's Disease Author(s) Verkhratsky, Alexei (UEM-P)
Olabarria, M. (GB)
Noristani, H. N. (GB)
Yeh, C. Y. (GB)
Rodríguez Arellano, Jose Julio (UEM-P)Source Title Neurotherapeutics. - : Springer - ISSN 1933-7213
Roč. 7, č. 4 (2010), s. 399-412Number of pages 14 s. Language eng - English Country US - United States Keywords Astrocytes ; neuroglia ; neurodegeneration Subject RIV FH - Neurology R&D Projects GA309/09/1696 GA ČR - Czech Science Foundation (CSF) GA305/08/1384 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z50390703 - UEM-P (2007-2013) UT WOS 000282198500007 EID SCOPUS 77957069073 DOI 10.1016/j.nurt.2010.05.017 Annotation In this manuscript we covered the specific involvement of astrocytes in various neurodegenerative diseases including Alzheimer's disease, Amyotrophic lateral sclerosis, Parkinson's disease and various forms of dementia. We demonstrate that early stages of neurodegenerative processes are associated with atrophy of astroglia, which causes disruptions in synaptic connectivity, disbalance in neurotransmitter homeostasis and neuronal death through increased excitotoxicity. Which at the later stages astrocytes became activated and contribute to neuro-inflammatory component of neurodegeneration. Workplace Institute of Experimental Medicine Contact Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Year of Publishing 2011
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