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Ca(2+) homeostasis, Ca(2+) signalling and somatodendritic vasopressin release in adult rat supraoptic nucleus neurones
- 1.0349377 - ÚEM 2011 RIV DE eng J - Journal Article
Komori, Y. - Tanaka, M. - Kuba, M. - Ishii, M. - Abe, M. - Kitamura, N. - Verkhratsky, Alexei - Shibuya, I. - Dayanithi, Govindan
Ca(2+) homeostasis, Ca(2+) signalling and somatodendritic vasopressin release in adult rat supraoptic nucleus neurones.
Cell Calcium. Roč. 48, č. 6 (2010), s. 324-332. ISSN 0143-4160. E-ISSN 1532-1991
Institutional research plan: CEZ:AV0Z50390703
Keywords : hypothalamus * cell bodies * nerve terminals
Subject RIV: FH - Neurology
Impact factor: 3.553, year: 2010
http://arl-repository.lib.cas.cz/uloziste_av/UEM-P/cav_un_epca-0349377_01.pdf
Multiple mechanisms that maintain Ca2+ homeostasis and provide for Ca2+ signalling operate in the somatas and neurohypophysial nerve terminals of supraoptic nucleus (SON) neurones. We demonstrate that in the fully mature adult rats: (i) all four Ca2+ homeostatic pathways, the Na+/Ca2+ exchanger, the endoplasmic reticulum Ca2+ pump, the plasmalemmal Ca2+ pump and mitochondria, act complementary in clearing Ca2+ loads in SON neurones; (ii) somatodendritic AVP release closely correlates with intracellular [Ca2+]i dynamics; and (iii) Ca2+ homeostatic systems in the somatas of SON neurones differ from those expressed in their terminals.
Permanent Link: http://hdl.handle.net/11104/0189633
Number of the records: 1