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Differential Modulation of N-Type Calcium Channels by mu-Opioid Receptors in Oxytocinergic Versus Vasopressinergic Neurohypophysial Terminals
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SYSNO ASEP 0349372 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Differential Modulation of N-Type Calcium Channels by mu-Opioid Receptors in Oxytocinergic Versus Vasopressinergic Neurohypophysial Terminals Author(s) Ortiz-Miranda, S. I. (US)
Dayanithi, Govindan (UEM-P) RID
Velazquez-Marrero, C. (US)
Custer, E. E. (US)
Treistman, S. N. (US)
Lemos, J. R. (US)Source Title Journal of Cellular Physiology. - : Wiley - ISSN 0021-9541
Roč. 225, č. 1 (2010), s. 276-288Number of pages 13 s. Language eng - English Country US - United States Keywords magnocellular neurons ; G-protein modulation ; neurohypophysis Subject RIV FH - Neurology CEZ AV0Z50390703 - UEM-P (2007-2013) UT WOS 000281295100031 EID SCOPUS 77956531735 DOI 10.1002/jcp.22263 Annotation Opioids modulate the electrical activity of magnocellular neurons (MCN) and inhibit neuropeptide release at their terminals in the neurohypophysis. We show that micro-opioid receptor (MOR) activation induces a stronger inhibition of oxytocin (OT) than vasopressin (AVP) release from isolated MCN terminals and found that N-type calcium channels in AVP terminals are differentially modulated by MOR. Workplace Institute of Experimental Medicine Contact Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Year of Publishing 2011
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