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Bral1: Its Role in Diffusion Barrier Formation and Conduction Velocity in the CNS
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SYSNO ASEP 0348934 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Bral1: Its Role in Diffusion Barrier Formation and Conduction Velocity in the CNS Author(s) Bekku, Y. (JP)
Vargová, Lýdia (UEM-P) RID
Goto, Y. (JP)
Voříšek, Ivan (UEM-P)
Dmytrenko, Lesia (UEM-P)
Narasaki, M. (JP)
Ohtsuka, A. (JP)
Fässler, R. (DE)
Ninomiya, Y. (JP)
Syková, Eva (UEM-P) RID
Oohashi, T. (JP)Source Title Journal of Neuroscience. - : Society for Neuroscience - ISSN 0270-6474
Roč. 30, č. 8 (2010), s. 3113-3123Number of pages 11 s. Language eng - English Country US - United States Keywords Bral1 ; central nervous system ; brain development Subject RIV FH - Neurology R&D Projects GA309/09/1597 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z50390512 - UEM-P (2005-2011) UT WOS 000274930500032 DOI 10.1523/JNEUROSCI.5598-09.2010 Annotation Brain-specific hyaluronan-binding link protein, Bral1, colocalizes and forms complexes with negatively charged extracellular matrix (ECM) proteins at the nodes of Ranvier in the myelinated white matter. The study report that the ECM no longer shows a nodal pattern and that CNS nerve conduction is markedly decreased in Bral1-deficient mice and the changes in the extracellular space diffusion parameters, measured by the real-time iontophoretic method and diffusion-weighted magnetic resonance imaging (MRI), suggest a reduction in the diffusion hindrances in the white matter of mutant mice. Workplace Institute of Experimental Medicine Contact Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Year of Publishing 2011
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