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Long-term adaptation to high doses of morphine causes desensitization of micro-OR- and delta-OR-stimulated G-protein response in forebrain cortex but does not decrease the amount of G-protein alpha subunits
- 1.0348192 - FGÚ 2011 RIV US eng J - Journal Article
Bouřová, Lenka - Vošahlíková, Miroslava - Kagan, D. - Dlouhá, Kateřina - Novotný, J. - Svoboda, Petr
Long-term adaptation to high doses of morphine causes desensitization of micro-OR- and delta-OR-stimulated G-protein response in forebrain cortex but does not decrease the amount of G-protein alpha subunits.
Medical Science Monitor. Roč. 16, č. 8 (2010), BR260-BR270. ISSN 1234-1010
R&D Projects: GA AV ČR(CZ) IAA500110606; GA MŠMT(CZ) LC554
Institutional research plan: CEZ:AV0Z50110509
Keywords : morphine * G-protein * opioid receptors
Subject RIV: CE - Biochemistry
Impact factor: 1.699, year: 2010
Our data support the view that the mechanism of the long-term adaptation to high doses of morphine is primarily based on desensitization of opioid receptors-response preferentially oriented to micro- and delta-opioid receptors. Prolonged exposure of rats to high doses of morphine results in decrease of the over-all output of opioid receptors-stimulated G-protein activity in the forebrain cortex but does not decrease the amount of these regulatory proteins
Permanent Link: http://hdl.handle.net/11104/0188782
Number of the records: 1