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Synthesis and biological activity of glycosyl-1H-1,2,3-triazoles
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SYSNO ASEP 0348175 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Synthesis and biological activity of glycosyl-1H-1,2,3-triazoles Author(s) Slámová, Kristýna (MBU-M) RID, ORCID
Marhol, Petr (MBU-M) RID
Bezouška, K. (CZ)
Lindkvist, L. (DK)
Hansen, G. S. (DK)
Křen, Vladimír (MBU-M) RID, ORCID
Jensen, H.H. (DK)Source Title Bioorganic and Medicinal Chemistry Letters. - : Elsevier - ISSN 0960-894X
Roč. 20, č. 14 (2010), s. 4263-4265Number of pages 3 s. Language eng - English Country GB - United Kingdom Keywords glycosidase inhibition ; beta-N-Acetylhexosaminidase ; N-Glycoside Subject RIV EE - Microbiology, Virology R&D Projects GD305/09/H008 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z50200510 - MBU-M (2005-2011) UT WOS 000279258800061 DOI 10.1016/j.bmcl.2010.04.151 Annotation Glycosyl 1,2,3-triazoles with a-D-gluco, b-D-gluco, a-D-galacto, b-D-galacto and b-2-acetamido-2-deoxygluco (GlcNAc) stereochemistry were prepared by reaction of the corresponding azides with vinyl acetate under microwave irradiation. The deprotected glucosyl and galactosyl triazoles did not display inhibitory activity against the tested glycosidases at 1 mM. Of the four fungal glycosidases evaluated, GlcNAc-triazole was found to be hydrolyzed by Talaromyces flavus CCF 2686 b-N-acetylhexosaminidase. β-GlcNActriazole was furthermore established to act as a strong ligand of rat and human natural killer cell activating receptors Workplace Institute of Microbiology Contact Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231 Year of Publishing 2011
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