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Reduced UVB-induced corneal damage caused by reactive oxygen and nitrogen species and decreased changes in corneal optics after trehalose treatment
- 1.0347608 - ÚEM 2011 RIV ES eng J - Journal Article
Čejková, Jitka - Čejka, Čestmír - Ardan, Taras - Širc, Jakub - Michálek, Jiří - Luyckx, J.
Reduced UVB-induced corneal damage caused by reactive oxygen and nitrogen species and decreased changes in corneal optics after trehalose treatment.
Histology and Histopathology. Roč. 25, č. 11 (2010), s. 1403-1416. ISSN 0213-3911. E-ISSN 1699-5848
Institutional research plan: CEZ:AV0Z50390512; CEZ:AV0Z40500505
Keywords : UVB rays * Rabbit cornea * Trehalose treatment
Subject RIV: FF - HEENT, Dentistry
Impact factor: 2.502, year: 2010
http://arl-repository.lib.cas.cz/uloziste_av/UEM-P/cav_un_epca-0347608_01.pdf
Trehalose, a nonreducing disaccharide of glucose, is synthetized as a stress responsive factor when cells are exposed to various stress conditions. In UVB-irradiated cornea the effect of trehalose was compared with eyes treated with buffered saline during irradiation. Results show that trehalose significantly reduced oxidative damage of the cornea induced by UVB rays. Trehalose reduced changes of corneal optics, suppressed apoptosis of corneal cells and decreased the formation of peroxynitrite, the reaction product between superoxide and nitric oxide.
Permanent Link: http://hdl.handle.net/11104/0188355
Number of the records: 1