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MicroRNA activity is suppressed in mouse oocytes
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SYSNO ASEP 0346835 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title MicroRNA activity is suppressed in mouse oocytes Author(s) Ma, J. (US)
Flemr, Matyáš (UMG-J)
Stein, P. (US)
Berninger, P. (CH)
Malík, Radek (UMG-J) RID
Zavolan, M. (CH)
Svoboda, Petr (UMG-J) RID
Schultz, R.M. (US)Source Title Current Biology. - : Cell Press - ISSN 0960-9822
Roč. 20, č. 3 (2010), s. 265-270Number of pages 6 s. Language eng - English Country GB - United Kingdom Keywords miRNA ; oocyte ; pluripotency Subject RIV EB - Genetics ; Molecular Biology R&D Projects GAP305/10/2215 GA ČR - Czech Science Foundation (CSF) ME09039 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) CEZ AV0Z50520514 - UMG-J (2005-2011) UT WOS 000274574100034 DOI 10.1016/j.cub.2009.12.042 Annotation Research article describing miRNA pathway analysis, which showed that miRNAs are normally produced but their activity is suppressed. This is a surprising and important discovery in the field of pluripotent stem cells because mikroRNAs are required for defining the cellular identity and their absence in the oocyte suggests a ling to the later establishment of pluripotency. Workplace Institute of Molecular Genetics Contact Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217 Year of Publishing 2011
Number of the records: 1