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Analysis of Amaryllidaceae Alkaloids from Zephyranthes robusta by GC-MS and Their Cholinesterase Activity
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SYSNO ASEP 0346356 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Analysis of Amaryllidaceae Alkaloids from Zephyranthes robusta by GC-MS and Their Cholinesterase Activity Author(s) Cahlíková, L. (CZ)
Kulhánková, A. (CZ)
Urbanová, Klára (UOCHB-X) RID
Valterová, Irena (UOCHB-X) RID, ORCID
Macáková, K. (CZ)
Kuneš, J. (CZ)Number of authors 6 Source Title Natural Product Communications - ISSN 1934-578X
Roč. 5, č. 8 (2010), s. 1201-1204Number of pages 4 s. Language eng - English Country US - United States Keywords Zephyranthes robusta ; Amaryllidaceae ; GC/MS ; acetylcholinesterase ; butyrylcholinesterase Subject RIV CC - Organic Chemistry CEZ AV0Z40550506 - UOCHB-X (2005-2011) UT WOS 000281074200010 Annotation From the bulbs of Zephyranthes robusta Baker (Amaryllidaceae), seven known compounds, belonging to four structural types of Amaryllidaceae alkaloids, were identified and quantified by GC-MS. The alkaloid extract from the bulbs showed promising acetylcholinesterase and butyrylcholinesterase inhibitory activities against HuAChE (IC50 = 35.9 ± 3.5 μg/mL) and HuBuChE (IC50 = 190.9 ± 8.2 μg/mL). Workplace Institute of Organic Chemistry and Biochemistry Contact asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Jana Procházková, Tel.: 220 183 418 Year of Publishing 2011
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