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Micelle-like nanoparticles of block copolymer poly(ethylene oxide)-block-poly(methacrylic acid) incorporating fluorescently substituted metallacarboranes designed as HIV protease inhibitor interaction probes
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SYSNO ASEP 0346345 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Micelle-like nanoparticles of block copolymer poly(ethylene oxide)-block-poly(methacrylic acid) incorporating fluorescently substituted metallacarboranes designed as HIV protease inhibitor interaction probes Author(s) Uchman, M. (CZ)
Cígler, Petr (UOCHB-X) RID, ORCID
Grüner, Bohumír (UACH-T) RID, SAI, ORCID
Procházka, K. (CZ)
Matějíček, P. (CZ)Number of authors 5 Source Title Journal of Colloid and Interface Science. - : Elsevier - ISSN 0021-9797
Roč. 348, č. 1 (2010), s. 129-136Number of pages 8 s. Language eng - English Country US - United States Keywords metallacarboranes ; micelles ; drug delivery Subject RIV CC - Organic Chemistry R&D Projects LC523 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) IAAX00320901 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) CEZ AV0Z40550506 - UOCHB-X (2005-2011) AV0Z40320502 - UACH-T (2005-2011) UT WOS 000278924600016 DOI 10.1016/j.jcis.2010.04.037 Annotation We prepared nanoparticles differing in morphology from double-hydrophilic block copolymer poly(ethylene oxide)-block-poly(methacrylic acid), PEO–PMA, and two types of fluorescein–[3-cobalt(III) bis(1,2-dicarbollide)] conjugates, GB176 and GB179, in alkaline buffer. GB176 molecule consists of fluorescein attached to the metallacarborane anion. In GB179 molecule, the fluorescein moiety connects two metallacarborane anions. The self-assembly is based on the unusual interaction of metallacarborane clusters with PEO blocks which form insoluble micellar cores. The GB176 containing nanoparticles are loose and irregular, while the GB179 ones are rigid and spherical. The micelles were studied by static and dynamic light scattering, fluorometry and atomic force microscopy. Since the metallacarborane conjugates act as potent inhibitors of HIV protease, the presented system is important from the point of view of drug delivery. Workplace Institute of Organic Chemistry and Biochemistry Contact asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Jana Procházková, Tel.: 220 183 418 Year of Publishing 2011
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