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Arsenicals produce stable progressive changes in DNA methylation patterns that are linked to malignant transformation of immortalized urothelial cells
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SYSNO ASEP 0345683 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Arsenicals produce stable progressive changes in DNA methylation patterns that are linked to malignant transformation of immortalized urothelial cells Author(s) Jensen, T.J. (US)
Novák, Petr (BC-A) RID, ORCID
Wnek, S.M. (US)
Gandolfi, A.J. (US)
Futscher, B. W. (US)Number of authors 5 Source Title Toxicology and Applied Pharmacology. - : Elsevier - ISSN 0041-008X
Roč. 241, č. 2 (2009), s. 221-229Number of pages 9 s. Language eng - English Country US - United States Keywords DNA methylation ; Epigenetic ; Arsenic Subject RIV EB - Genetics ; Molecular Biology CEZ AV0Z50510513 - UMBR-M, BC-A (2005-2011) UT WOS 000271712600011 DOI 10.1016/j.taap.2009.08.019 Annotation Aberrant DNA methylation participates in carcinogenesis and is a molecular hallmark of a tumor cell. We used a model of arsenical-induced malignant transformation of immortalized human urothelial cells and DNA methylation microarrays to examine the extent and temporal nature of changes in DNA methylation that occur during the transition from immortal to malignantly transformed. Our data presented herein suggest that during arsenical-induced malignant transformation, aberrant DNA methylation occurs non-randomly, progresses gradually at hundreds of gene promoters, and alters expression of the associated gene, and these changes are coincident with the acquisition of malignant properties, such as anchorage independent growth and tumor formation in immunocompromised mice. Workplace Biology Centre (since 2006) Contact Dana Hypšová, eje@eje.cz, Tel.: 387 775 214 Year of Publishing 2011
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