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Cell signalling in CNS and immune system in depression and during antidepressant treatment: focus on glial and natural killer cells
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SYSNO ASEP 0341156 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Cell signalling in CNS and immune system in depression and during antidepressant treatment: focus on glial and natural killer cells Author(s) Kovářu, H. (CZ)
Páv, M. (CZ)
Kovářů, František (UZFG-Y)
Raboch, J. (CZ)
Fišerová, Anna (MBU-M) RIDSource Title Neuroendocrinology Letters - ISSN 0172-780X
Roč. 30, č. 4 (2009), s. 421-428Number of pages 8 s. Language eng - English Country SE - Sweden Keywords astrocyte ; cAMP ; depression Subject RIV ED - Physiology R&D Projects IAA601680801 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) CEZ AV0Z50450515 - UZFG-Y (2005-2011) AV0Z50200510 - MBU-M (2005-2011) UT WOS 000273879400001 Annotation There is a considerable evidence that inflammatory response and immune system changes are the part of depression. Components of cellular immune system natural killer cells, important effectors of immune surveillance, are sensitive to stress response, and their functions are compromised in depressive subjects. Many lines of evidence also point to the loss of both neuronal and glial plasticity and neurotrophic factor support under chronic stress or in depression. There is an increasing knowledge of the role of astrocytic cells in neuroplastic processes and neurotransmitter metabolism. Alterations in the glial populations are observed in major depressive subjects. Antidepressant treatment is modulating glial signalization cascades, increasing production of neurotrophic molecules, supporting neuroplasticity processes, and also modulating functions of natural killers. At the level of membrane signalling, antidepressants show a direct influence upon G alpha subunit levels in both immune system and CNS. These findings support the view that antidepressants influence activity of natural killer and astrocytic populations, and this could be of importance in the depression etiopathogenesis and/or treatment. Workplace Institute of Animal Physiology and Genetics Contact Jana Zásmětová, knihovna@iapg.cas.cz, Tel.: 315 639 554 Year of Publishing 2010
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