Wnt/beta-catenin signaling blockade promotes neuronal induction and dopaminergic differentiation in embryonic stem cells

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SYSNO ASEP	0341089
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Wnt/beta-catenin signaling blockade promotes neuronal induction and dopaminergic differentiation in embryonic stem cells
Author(s)	Čajánek, L. (SE) Ribeiro, D. (SE) Liste, I. (SE) Parish, C.L. (SE) Bryja, Vítězslav (BFU-R)_{RID, ORCID} Arenas, E. (SE)
Number of authors	6
Source Title	Stem Cells. - : Oxford University Press - ISSN 1066-5099 Roč. 27, č. 12 (2009), s. 2917-2927
Number of pages	11 s.
Language	eng - English
Country	US - United States
Keywords	embryonic stem cells ; Wnt pathway ; dopaminergic neurons
Subject RIV	BO - Biophysics
CEZ	AV0Z50040507 - BFU-R (2005-2011)
	AV0Z50040702 - BFU-R (2007-2013)
UT WOS	000273569800005
DOI	10.1002/stem.210
Annotation	Embryonic stem cells (ESCs) represent not only a promising source of cells for cell replacement therapy, but also a tool to study the molecular mechanisms underlying cellular signaling and dopaminergic (DA) neuron development. Here we used mouse ESCs (mESCs) lacking Wnt1 or the low-density-lipoprotein receptor-related protein 6 (LRP6) to decipher the action of Wnt/b-catenin signaling on DA neuron development in mESCs.
Workplace	Institute of Biophysics
Contact	Jana Poláková, polakova@ibp.cz, Tel.: 541 517 244
Year of Publishing	2010

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