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Dissociation of nystatin and amphotericin analogues: characterization of minor anti-fungal macrolides
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SYSNO ASEP 0340845 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Dissociation of nystatin and amphotericin analogues: characterization of minor anti-fungal macrolides Author(s) Ulrych, Aleš (MBU-M) RID
Derrick, P.J. (NZ)
Adámek, F. (CZ)
Novák, Petr (MBU-M) RID, ORCID
Lemr, Karel (MBU-M) RID, ORCID
Havlíček, Vladimír (MBU-M) RID, ORCIDSource Title European Journal of Mass Spectrometry. - : Sage - ISSN 1469-0667 - ISSN 1365-0718
Roč. 16, č. 1 (2010), s. 73-80Number of pages 8 s. Language eng - English Country GB - United Kingdom Keywords antibiotics ; nystatin ; amphotericin Subject RIV EE - Microbiology, Virology R&D Projects LC07017 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) CEZ AV0Z50200510 - MBU-M (2005-2011) UT WOS 000274290200008 DOI 10.1255/ejms.1027 Annotation Tandem mass spectrometry combined with Fourier transform ion cyclotron resonance (FTICR) has been the basis for rationalizing the fragmentation mechanisms of antifungal macrolides nystatin A1, amphotericin B and pimaricin. The positive ion mass spectra were not informative, however, the dissociation of deprotonated molecules led to structurally significant ring-opened fragments. Using this approach of tandem FTICR mass spectrometry (MS/MS) and electrospray ionization (ESI) coupled with high-performance liquid chromatography (HPLC), eleven macrolide natural analogues or degradation products were characterized in the nystatin mixture Workplace Institute of Microbiology Contact Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231 Year of Publishing 2010
Number of the records: 1