Number of the records: 1
Molecular Characterization of Clinical Isolates of Human Immunodeficiency Virus Resistant to the Protease Inhibitor Darunavir
- 1.
SYSNO ASEP 0330753 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Molecular Characterization of Clinical Isolates of Human Immunodeficiency Virus Resistant to the Protease Inhibitor Darunavir Author(s) Grantz Šašková, Klára (UOCHB-X) RID, ORCID
Kožíšek, Milan (UOCHB-X) RID, ORCID
Řezáčová, Pavlína (UOCHB-X) RID, ORCID
Brynda, Jiří (UMG-J) RID
Yashina, T. (US)
Kagan, R. M. (US)
Konvalinka, Jan (UOCHB-X) RID, ORCIDNumber of authors 7 Source Title Journal of Virology - ISSN 0022-538X
Roč. 83, č. 17 (2009), s. 8810-8818Number of pages 9 s. Language eng - English Country US - United States Keywords HIV-1 protease ; darunavir ; X-ray structural analysis ; protease inhibitor ; mutations Subject RIV CE - Biochemistry R&D Projects 1M0508 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) CEZ AV0Z40550506 - UOCHB-X (2005-2011) AV0Z50520514 - UMG-J (2005-2011) UT WOS 000269122300048 DOI 10.1128/JVI.00451-09 Annotation In this work we report structural and enzymological analysis of a panel of clinically derived mutant HIV-1 proteases with high levels of phenotypic resistance to darunavir. Recombinant virus phenotypic characterization, enzyme kinetics, and X-ray structural analysis are used to explain darunavir resistance development in HIV-positive patiens. Workplace Institute of Organic Chemistry and Biochemistry Contact asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Jana Procházková, Tel.: 220 183 418 Year of Publishing 2010
Number of the records: 1