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Lasioglossins: Three novel antimicrobial peptides from the venom of the eusocial bee Lasioglossum laticeps (Hymenoptera: Halictidae)
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SYSNO ASEP 0329288 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Lasioglossins: Three novel antimicrobial peptides from the venom of the eusocial bee Lasioglossum laticeps (Hymenoptera: Halictidae) Author(s) Čeřovský, Václav (UOCHB-X) RID, ORCID
Buděšínský, Miloš (UOCHB-X) RID, ORCID
Hovorka, Oldřich (UOCHB-X)
Cvačka, Josef (UOCHB-X) RID, ORCID
Voburka, Zdeněk (UOCHB-X)
Slaninová, Jiřina (UOCHB-X)
Borovičková, Lenka (UOCHB-X)
Fučík, Vladimír (UOCHB-X) RID
Bednárová, Lucie (UOCHB-X) RID, ORCID
Votruba, Ivan (UOCHB-X) RID
Straka, J. (CZ)Number of authors 11 Source Title Chembiochem. - : Wiley - ISSN 1439-4227
Roč. 10, č. 12 (2009), s. 2089-2099Number of pages 11 s. Language eng - English Country DE - Germany Keywords lasioglossins ; peptides ; Lasioglossum laticeps Subject RIV CC - Organic Chemistry R&D Projects GA203/08/0536 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z40550506 - UOCHB-X (2005-2011) UT WOS 000269279700024 DOI 10.1002/cbic.200900133 Annotation Three novel antimicrobial peptides H-Val-Asn-Trp-Lys-Lys-Val-Leu-Gly-Lys-Ile-Ile-Lys-Val-Ala-Lys-NH2 (LL-I), H-Val-Asn-Trp-Lys-Lys-Ile-Leu-Gly-Lys-Ile-Ile-Lys-Val-Ala-Lys-NH2 (LL-II) and H-Val-Asn-Trp-Lys-Lys-Ile-Leu-Gly-Lys-Ile-Ile-Lys-Val-Val-Lys-NH2 (LL-III) designated lasioglossins were identified in the venom of the wild be Lasioglossum laticeps. They possess high antimicrobial activity against both Gram-positive and -negative bacteria and low hemolytic activity. As indicated by CD and NMR spectroscopy, lasioglossins can adopt an amphipathic alpha-helical secondary structure in an anisotropic environment such as the bacterial cell membrane. NMR study confirmed that this alpha-helical structure is curved with a concave hydrophobic and convex hydrophilic side. Workplace Institute of Organic Chemistry and Biochemistry Contact asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Jana Procházková, Tel.: 220 183 418 Year of Publishing 2010
Number of the records: 1