The effect of uric acid on homocysteine-induced endothelial dysfunction

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SYSNO ASEP	0328477
Document Type	A - Abstract
R&D Document Type	The record was not marked in the RIV
R&D Document Type	Není vybrán druh dokumentu
Title	The effect of uric acid on homocysteine-induced endothelial dysfunction
Title	Vliv kyseliny močové na endoteliální dysfunkci indukovanou homocysteinem
Author(s)	Papežíková, Ivana (BFU-R) Pekarová, Michaela (BFU-R)_RID Kubala, Lukáš (BFU-R)_{RID, ORCID} Lojek, Antonín (BFU-R)_RID
Source Title	Programme & Abstracts. - Brno, 2009 - ISSN 1337-6853 S. 135
Number of pages	1 s.
Action	TOXCON 2009, 14th Interdisciplinary Toxicology Conference
Event date	01.06.2009-03.06.2009
VEvent location	Brno
Country	CZ - Czech Republic
Event type	EUR
Language	eng - English
Country	CZ - Czech Republic
Keywords	uric acid ; endothelial dysfunction ; nitric oxide
Subject RIV	BO - Biophysics
R&D Projects	GP204/07/P539 GA ČR - Czech Science Foundation (CSF)
CEZ	AV0Z50040507 - BFU-R (2005-2011)
	AV0Z50040702 - BFU-R (2007-2013)
Annotation	The effect of uric acid on endothelial dysfunction in bovine aortic endothelial cells was studied. It was found that uric acid did not have any protective effect in the cells with preexisting dysfunction and induced endothelial dysfunction per se. This effect was caused by enhancing superoxide generation by endothelial cells.
Workplace	Institute of Biophysics
Contact	Jana Poláková, polakova@ibp.cz, Tel.: 541 517 244
Year of Publishing	2010

Number of the records: 1