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Effect of endocrine disruptors on mammalian fertility
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SYSNO ASEP 0323271 Document Type C - Proceedings Paper (int. conf.) R&D Document Type The record was not marked in the RIV Title Effect of endocrine disruptors on mammalian fertility Author(s) Pěknicová, Jana (BTO-N) RID
Nováková, Vendula (BTO-N)
Buckiová, Daniela (UEM-P)
Boubelík, Michael (BTO-N)Number of authors 4 Source Title Scientific session - dedicated to the 70th anniversary of the Institute of Biology and Immunology of Reproduction, Scientific session. - Sofia : Bulgarian Academy of Scientes, 2008 Pages s. 1-75 Number of pages 1 s. Action Scientific session dedicated to the 70th Anniversary of the Institute of biology and Immunology of Reproduction Event date 23.10.2008 VEvent location Sofia Country BG - Bulgaria Event type EUR Language eng - English Country BG - Bulgaria Keywords endocrine disruptor ; fertility ; spermatozoa Subject RIV DN - Health Impact of the Environment Quality R&D Projects EUREKA OE211 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) 1M06011 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) 2B06151 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) CEZ AV0Z50520701 - BTO-N (2007-2013) Annotation Endocrine system is one of the most important regulatory systems in the mammalian body. The endocrine disruptors (ED) can disrupt the function of the endocrine system but their activity is not a result of the physiological regulation. The effect of low dose of selected ED, bisphenol-A (BPA), p-nonylphenol (NP), diethylstilbestrol (DES), genistein (GEN), resveratrol (RES)), hormone (17α-ethynylestradiol (EE2)) and polybrominated compound (tetrabromobisphenol A (TBBPA)) within development of reproductive tract in outbred CD1 mice was tested. BPA and NP had a negative effect on reproductive organs morphology and mouse spermatozoa. The fertility of mice exposed to DES was disrupted. Contrary to that, treatment by GEN and RES had no effect on the fertility of mice but had some effect on their reproductive parameters except for sperm integrity. Synthetic hormone (EE2) and polybrominated compound (TBBPA) also affected on the organ weight, reproductive parameters and sperm quality. Workplace Institute of Biotechnology Contact Monika Kopřivová, Monika.Koprivova@ibt.cas.cz, Tel.: 325 873 700 Year of Publishing 2011
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