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A.c. impedance and constant current chronopotentiometry in detection of changes in protein structures
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SYSNO ASEP 0311424 Document Type A - Abstract R&D Document Type The record was not marked in the RIV R&D Document Type Není vybrán druh dokumentu Title A.c. impedance and constant current chronopotentiometry in detection of changes in protein structures Title A.c. impedance a chronopotentiometrie s konstantním proudem při detekci změn proteinové struktury Author(s) Ostatná, Veronika (BFU-R) RID, ORCID
Paleček, Emil (BFU-R) RID, ORCIDSource Title Abstract. - Třesť, 2008
S. 1Number of pages 1 s. Action 41st Heyrovský Discussion on Electrochemical Impedance Analysis Event date 15.06.2008-19.06.2008 VEvent location Třešť Country CZ - Czech Republic Event type CST Language eng - English Country CZ - Czech Republic Keywords a.c. impedance ; constant current chronopotentiometry ; denaturation and aggregation Subject RIV BO - Biophysics R&D Projects GP202/07/P497 GA ČR - Czech Science Foundation (CSF) LC06035 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) CEZ AV0Z50040507 - BFU-R (2005-2011) AV0Z50040702 - BFU-R (2007-2013) Annotation We studied native and denatured BSA by means of constant current chronopotentiometric stripping analysis (CPSA) as well as a.c. impedance. What are the reasons for the excellent sensitivity of CPS for changes in protein structure? In CPSA the potential changes are much faster (if no electrode process is going on as surface denaturation) than in usual a.c. voltammetry. On the other hand using a.c. impedance we obtained excellent correlation between the adsorption/desorption behavior of alpha-synuclein (involved in Parkinson disease) in the early stage of its aggregation and changes in the ability of alpha synuclein to catalyze the hydrogen evolution on the mercury electrode. Workplace Institute of Biophysics Contact Jana Poláková, polakova@ibp.cz, Tel.: 541 517 244 Year of Publishing 2009
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