Identification of renal Cd36 as a determinant of blood pressure and risk for hypertension

Pravenec, Michal; Churchill, P. C.; Churchill, M. C.; Vyklický, O.; Kazdová, L.; Aitman, T. J.; Petretto, E.; Hubner, N.; Wallace, C. A.; Zimdahl, H.; Zídek, Václav; Landa, Vladimír; Dunbar, J.; Bidani, A.; Griffin, K.; Qi, N.; Maxová, M.; Křen, Vladimír; Mlejnek, Petr; Wang, J.; Kurtz, T. W.

doi:https://dx.doi.org/10.1038/ng.164

Number of the records: 1

Identification of renal Cd36 as a determinant of blood pressure and risk for hypertension

1.

SYSNO ASEP	0311214
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Identification of renal Cd36 as a determinant of blood pressure and risk for hypertension
Title	Identifikace renálního Cd36 jako determinanty krevního tlaku a rizika hypertenze
Author(s)	Pravenec, Michal (FGU-C)_{RID, ORCID} Churchill, P. C. (US) Churchill, M. C. (US) Vyklický, O. (CZ) Kazdová, L. (CZ) Aitman, T. J. (GB) Petretto, E. (GB) Hubner, N. (DE) Wallace, C. A. (GB) Zimdahl, H. (DE) Zídek, Václav (FGU-C)_RID Landa, Vladimír (FGU-C)_RID Dunbar, J. (US) Bidani, A. (US) Griffin, K. (US) Qi, N. (US) Maxová, M. (CZ) Křen, Vladimír (FGU-C) Mlejnek, Petr (FGU-C)_{RID, ORCID} Wang, J. (US) Kurtz, T. W. (US)
Source Title	Nature Genetics. - : Nature Publishing Group - ISSN 1061-4036 Roč. 40, č. 8 (2008), s. 952-954
Number of pages	3 s.
Language	eng - English
Country	US - United States
Keywords	spontaneously hypertensive rat ; Cd36 ; hypertension
Subject RIV	EB - Genetics ; Molecular Biology
R&D Projects	NR8545 GA MZd - Ministry of Health (MZ)
	NR8495 GA MZd - Ministry of Health (MZ)
	1M0520 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
	ME08006 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
	1P05ME791 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
	NR9359 GA MZd - Ministry of Health (MZ)
	IAA500110604 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR)
	IAA500110805 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR)
CEZ	AV0Z50110509 - FGU-C (2005-2011)
UT WOS	000258026900010
DOI	https://doi.org/10.1038/ng.164
Annotation	To identify renally expressed genes that influence risk for hypertension, we integrated expression quantitative trait locus (QTL) analysis of the kidney with genome-wide correlation analysis of renal expression profiles and blood pressure in recombinant inbred strains derived from the spontaneously hypertensive rat (SHR). This strategy, together with renal transplantation studies in SHR progenitor, transgenic and congenic strains, identified deficient renal expression of Cd36 encoding fatty acid translocase as a genetically determined risk factor for spontaneous hypertension
Workplace	Institute of Physiology
Contact	Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400
Year of Publishing	2009

Number of the records: 1