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Multiple parasites mediate balancing selection at two MHC class II genes in the fossorial water vole: insights from multivariate analyses and population genetics
- 1.0310942 - ÚBO 2009 RIV GB eng J - Journal Article
Tollenaere, C. - Bryja, Josef - Galan, M. - Cadet, P. - Deter, J. - Chaval, Y. - Berthier, K. - Ribas Salvador, A. - Voutilainen, L. - Laakkonen, J. - Henttonen, H. - Cosson, J.-F. - Charbonnel, N.
Multiple parasites mediate balancing selection at two MHC class II genes in the fossorial water vole: insights from multivariate analyses and population genetics.
[Balancujici selekce na dvou MHC Class II genech je zprostředkována více druhy parazitů: výsledky vícerozměrných analýz a populační genetiky.]
Journal of Evolutionary Biology. Roč. 21, č. 5 (2008), s. 1307-1320. ISSN 1010-061X. E-ISSN 1420-9101
EU Projects: European Commission(XE) 10284 - EDEN
Institutional research plan: CEZ:AV0Z60930519
Keywords : co-inertia * DQA and DRB MHC genes * immunogenetics * multivariate analysis * parasite-mediated balancing selection
Subject RIV: EB - Genetics ; Molecular Biology
Impact factor: 3.471, year: 2008
We investigated the factors mediating selection acting on two MHC class II genes (DQA and DRB) in water vole (Arvicola scherman) natural populations in the French Jura Mountains. Population genetics showed significant homogenity in allelic frequencies at the DQA1 locus as opposed to neutral markers (nine microsatellites), indicating balancing selection acting on this gene. Moreover, almost exhaustive screening for parasites, including gastrointestinal helminths, brain coccidia and antibodies against viruses responsible for zoonoses, was carried out. We applied a co-inertia approach to the genetic and parasitological data sets to avoid statistical problems related to multiple testing. Two alleles, Arte-DRB-11 and Arte-DRB-15, displayed antagonistic associations with the nematode Trichuris arvicolae, revealing the potential parasite-mediated selection acting on DRB locus. Selection mechanisms acting on the two MHC class II genes thus appeared different.
V práci jsme analyzovali faktory, které jsou zodpovědné za selekci působící na dva MHC Class II geny (DQA a DRB) v populacích hryzce vodního v pohoří Jura (Francie). Balancující selekce působila výrazněji na gen DQA než na gen DRB. Vyčerpávající screening parazitofauny a následné vícerozměrné analýzy co-inertie prokázaly, že dvě alely genu DRB vykazovaly antagonistické asociace s parazitem Trichuris arvicolae. Selekční mechanismy působící na dva MHC Class II geny se tedy zdají být rozdílné, nicméně overdominance jako selekční mechanismus je dosti nepravděpodobný.
Permanent Link: http://hdl.handle.net/11104/0162675
Number of the records: 1