Genetically modified dendritic cell-based cancer vaccines
1.
SYSNO ASEP
0191269
Document Type
J - Journal Article
R&D Document Type
Journal Article
Subsidiary J
Ostatní články
Title
Genetically modified dendritic cell-based cancer vaccines
Author(s)
Bubeník, Jan (UMG-J)
Source Title
Folia Biologica. - : Univerzita Karlova v Praze
- ISSN 0015-5500
Roč. 47, č. 5 (2001), s. 153-155
Number of pages
3 s.
Language
eng - English
Country
CZ - Czech Republic
Keywords
dendritic cells ; cancer vaccines
Subject RIV
EB - Genetics ; Molecular Biology
R&D Projects
NC5526 GA MZd - Ministry of Health (MZ)
Annotation
The capacity to present antigens, activate naive T cells and induce primary cellular immunity make DC attractive vehicles for delivery of therapeutic cancer vaccines. Genetically modified DC vaccines can be prepared by transfection with polynucleotides coding for oncoproteins, immunostimulatory cytokines and/or co-stimulatory molecules, transduction with recombinant viral vectors encoding these molecules and tumour cell-DC fusion. The therapeutic effects of these vaccines .I.in ./I. .I.vitro ./I.and .I.in vivo ./I.are discussed.
