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Voltammetry of Protonated Anesthetics at a Liquid Membrane: Evaluation of the Drug Propagation
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SYSNO ASEP 0180921 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Ostatní články Title Voltammetry of Protonated Anesthetics at a Liquid Membrane: Evaluation of the Drug Propagation Author(s) Samec, Zdeněk (UFCH-W) RID, ORCID
Trojánek, Antonín (UFCH-W) RID
Langmaier, Jan (UFCH-W) RID, ORCID, SAI
Samcová, E. (CZ)
Málek, Jiří (UFCH-W)Source Title Electroanalysis. - : Wiley - ISSN 1040-0397
Roč. 12, č. 12 (2000), s. 901-904Language eng - English Country DE - Germany Subject RIV CG - Electrochemistry CG - Electrochemistry R&D Projects IAA4040709 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) IAA4040902 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) IZ4398 GA MZd - Ministry of Health (MZ) KSK2040602 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) CEZ AV0Z4040901 - UFCH-W Annotation Voltammetry is used to study the transfer of protonated forms of local anesthetics (procaine, tetracaine, prilocaine, etc.) across a supported o-NPOE membrane.Ion diffusion coefficients and ion transfer potentials were obtained. It is shown that the pharmacological potency of local anesthetics correlates with standard ion transfer potentials of their protonated forms.It is proposed that the drug propagation involves the transfer of the ionic rather than uncharged anesthetic across the cell membrane. Workplace J. Heyrovsky Institute of Physical Chemistry Contact Michaela Knapová, michaela.knapova@jh-inst.cas.cz, Tel.: 266 053 196 Year of Publishing 2001
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