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Kinetics of formation of specific styrene oxide adducts in double-stranded DNA
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SYSNO ASEP 0173460 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Ostatní články Title Kinetics of formation of specific styrene oxide adducts in double-stranded DNA Author(s) Koskinen, M. (SE)
Vodičková, L. (CZ)
Vodička, Pavel (UEM-P) RID
Warner, S. C. (SE)
Hemminki, K. (SE)Source Title Chemico-Biological Interactions. - : Elsevier - ISSN 0009-2797
Roč. 138, č. 2 (2001), s. 111-124Number of pages 13 s. Language eng - English Country IE - Ireland Keywords biomonitoring ; DNA adducts Subject RIV EA - Cell Biology R&D Projects GA313/99/1460 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z5039906 - UEM-P Annotation In order to compare the intrinsic reactivity of the different nucleophilic sites in DNA towards SO and to evaluate the candidates for human biomonitoring we have determined the second-order tate constants and stabilities of several SC-adducts in double-stranded DNA. These include ?- and ß-isomers of N7-substituted and ?N2-substituted guanines, ?- and ßN3-substituted and ?N6-substituted adenines as well as ßN3-and ?N4-substituted cytosines. Workplace Institute of Experimental Medicine Contact Arzuv Čaryjeva, arzuv.caryjeva@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Year of Publishing 2002
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