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Adenine N3 is a main alkylation site of styrene oxide in double-stranded DNA
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SYSNO ASEP 0173447 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Ostatní články Title Adenine N3 is a main alkylation site of styrene oxide in double-stranded DNA Author(s) Koskinen, M. (SE)
Vodička, Pavel (UEM-P) RID
Hemminki, K. (SE)Source Title Chemico-Biological Interactions. - : Elsevier - ISSN 0009-2797
Roč. 124, - (2000), s. 13-27Number of pages 15 s. Language eng - English Country NL - Netherlands Keywords styrene oxide ; DNA adducts Subject RIV DN - Health Impact of the Environment Quality R&D Projects GA313/99/1460 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z5039906 - UEM-P Annotation The results indicated that in double-stranded DNA N-7 of guanine and N-3 of adenine account for 97% of alkylation by SO. However, these abundant adducts are not stable, the half-life of depurination in DNA for 3-substituted adenines being ~ 10 and ~ 20 h, for ?- and ß-isomers, respectively, and 51 h for both isomers of 7-substituted guanines. Workplace Institute of Experimental Medicine Contact Arzuv Čaryjeva, arzuv.caryjeva@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Year of Publishing 2002
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