DNA double-strand breaks induce formation of RP-A/Ku foci on in vitro reconstituted Xenopus sperm nuclei
1.
SYSNO ASEP
0173418
Document Type
J - Journal Article
R&D Document Type
Journal Article
Subsidiary J
Ostatní články
Title
DNA double-strand breaks induce formation of RP-A/Ku foci on in vitro reconstituted Xenopus sperm nuclei
Author(s)
Grandi, P. (CH) Eltsov, Michail (UEM-P) Nielsen, I. (CH) Raška, Ivan (UEM-P)
Source Title
Journal of Cell Science. - : Company of Biologists
- ISSN 0021-9533
Roč. 114, č. 18 (2001), s. 3345-3357
Number of pages
13 s.
Language
eng - English
Country
US - United States
Keywords
unscheduled DNA synthesis
Subject RIV
EB - Genetics ; Molecular Biology
R&D Projects
GA302/99/0587 GA ČR - Czech Science Foundation (CSF)
GA304/00/1481 GA ČR - Czech Science Foundation (CSF)
CEZ
AV0Z5039906 - UEM-P
Annotation
The Xenopus in vitro system allows for the generation of specific DNA ds breaks, RP-A and Ku can be used as markers for these lesions and the repair of this type of DNA damage can be studied under conditions of a normal nuclear environment.
